Reference GRCh38.p14 Primary Assembly Genomic Model RNAs and proteins are also reported here. RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternateĪssemblies. Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as The following sections contain reference sequences that belong to a RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). Status: REVIEWED Description Transcript Variant: This variant (3), also known as SMAD6B, includes an alternate exon, compared to variant 1. Location: 322 → 494 MH2_SMAD_6 C-terminal Mad Homology 2 (MH2) domain in SMAD6 Location: 160 → 273 MH1_SMAD_6 N-terminal Mad Homology 1 (MH1) domain in SMAD6 cd10499 Status: REVIEWED Description Transcript Variant: This variant (1) encodes the supported protein. See identical proteins and their annotated locations for NP_005576.3 NM_005585.5 → NP_005576.3 mothers against decapentaplegic homolog 6 NG_012244.2 RefSeqGene Range 4901.85514 Download GenBank, FASTA, Sequence Viewer (Graphics) This section to the one reported in Genomic regions, Identify version mismatches by comparing the version of the RefSeq in These reference sequences are curated independently of the genomeĪnnotation cycle, so their versions may not match the RefSeq versions in the current These reference sequences exist independently of genome builds. Expression Broad expression in lung (RPKM 6.3), placenta (RPKM 2.8) and 18 other tissues See more Orthologs mouse all NEW Try the new Gene table Multiple transcript variants have been found for this gene. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. Full Name SMAD family member 6 provided by HGNC Primary source HGNC:HGNC:6772 See related Ensembl:ENSG00000137834 MIM:602931 AllianceGenome:HGNC:6772 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as AOVD2 MADH6 MADH7 HsT17432 Summary The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C.
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